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Article

The Inhibitory Effect of Betanin on Adipogenesis in 3T3-L1 Adipocytes

1Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Taiwan, ROC

2Department of Anesthesiology, Chi-Mei Medical Center, Taiwan, ROC

3Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC

4Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District, Tainan, Taiwan, ROC


Journal of Food and Nutrition Research. 2019, Vol. 7 No. 6, 447-451
DOI: 10.12691/jfnr-7-6-6
Copyright © 2019 Science and Education Publishing

Cite this paper:
Jen-Yin Chen, Chin-Chen Chu, Shih-Ying Chen, Heuy-Ling Chu, Pin-Der Duh. The Inhibitory Effect of Betanin on Adipogenesis in 3T3-L1 Adipocytes. Journal of Food and Nutrition Research. 2019; 7(6):447-451. doi: 10.12691/jfnr-7-6-6.

Correspondence to: Pin-Der  Duh, Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District, Tainan, Taiwan, ROC. Email: ipdduh@mail.cnu.edu.tw

Abstract

Betanin, a natural pigment that presents ubiquitously in plants, has been reported to show biological effects. However, not much is known on the effectiveness of betanin in regulating fat accumulation. Therefore, the aim of this study is to explore the inhibitory effect of betanin on adipogenesis in 3T3-L1 adipocytes and its mechanism action. The results show betanin significantly inhibited oil red O-stained material (OROSM) and triglyceride levels in 3T3-L1 adipocytes, indicating betanin inhibited lipid accumulation in 3T3-L1 adipocytes. In addition, the peroxisome proliferator–activated receptor γ (PPARγ) expression was significantly inhibited in the betanin-treated adipocytes, implying that betanin suppressed the cellular PPARγexpression in 3T3-L1 adipocytes. Moreover, the suppression of lipid accumulation by betanin occurred by decreasing the gene expression of PPARγ, CCAAT-enhancer-binding protein α (C/EBPα) and sterol regulatory element binding protein 1c (SREBP-1c). Taken together, these findings suggest betanin may be a mediator of adipocyte accumulation, leading to the inhibition of lipogenesis in 3T3-L1 adipocytes and betanin is therefore potentially useful for designing new antiadipogenic agent.

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