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Vogelstein, B., Lane, D. and Levine, A. J. Surfing the p53 network. Nature. 2000, 408, 307-310.

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Article

An In Silico Study: Can the Modulation of miRNA Expression through a Diet that Promotes the Production of Butyrate and Consumption of Genistein and Quercetin, Impact Cancer?

1FMHS, University of Auckland, Auckland 1023, New Zealand

2Auckland Cancer Society Research Centre, School of Medical Sciences, FMHS, University of Auckland, Auckland 1023, New Zealand

3Discipline of Nutrition and Dietetics, School of Medical Sciences, FMHS, University of Auckland, Auckland 1023, New Zealand


Journal of Food and Nutrition Research. 2018, Vol. 6 No. 12, 748-759
DOI: 10.12691/jfnr-6-12-5
Copyright © 2018 Science and Education Publishing

Cite this paper:
Sung-Min Jun, Karen S. Bishop. An In Silico Study: Can the Modulation of miRNA Expression through a Diet that Promotes the Production of Butyrate and Consumption of Genistein and Quercetin, Impact Cancer?. Journal of Food and Nutrition Research. 2018; 6(12):748-759. doi: 10.12691/jfnr-6-12-5.

Correspondence to: Karen  S. Bishop, Auckland Cancer Society Research Centre, School of Medical Sciences, FMHS, University of Auckland, Auckland 1023, New Zealand. Email: k.bishop@auckland.ac.nz

Abstract

Diet plays a major role in regulating cancer. Bioactives such as polyphenols and isoflavones found naturally in our food are increasingly being recognised as regulators of interest. These compounds can regulate cancer pathways through microRNAs which are critical in modulating expression of various genes. We carried out a literature review wherein we assessed the impact of three dietary compounds, namely butyrate, genistein and quercetin, on miRNA expression followed by an in silico study utilising DIANA-miRPathv3 software. Our literature search found that miR-34a, miR-200a-3p and miR-200b-3p were modulated by all three compounds while miR-221, miR-222, miR-29a, miR-3935 and miR-574-3p were modulated by both genistein and butyrate and let-7b, miR-194, miR-96-5p and miR-424 were modulated by butyrate and quercetin. The in silico analysis identified key pathways of interest such as “bladder cancer” which had significant interactions with the miRNAs modulated by the dietary compounds.

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