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Jain, M., Kapadia, R., Jadeja, R.N., Thounaojam, M.C., Devkar, R.V. and Mishra, S.H. Protective role of standardized Feronia limoniastem stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity. Annals of Hematology 11, 935-943, 2012.

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Article

Antioxidant Potential of Stem Bark Extract of Shorea roxburghii against CCl4 induced Liver Damage in Wistar Rats

1Department of Chemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Tamilnadu, India

2Department of Chemistry, Sun Arts and Science College, Tiruvannamalai, Tamilnadu, India

3Department of Chemistry, Periyar University, Salem, Tamilnadu, India


American Journal of Food and Nutrition. 2017, Vol. 5 No. 4, 121-125
DOI: 10.12691/ajfn-5-4-2
Copyright © 2017 Science and Education Publishing

Cite this paper:
V. Menakapriya, K. Karthikarathi, R. Subramanian, A. Kathirvel, V. Raj. Antioxidant Potential of Stem Bark Extract of Shorea roxburghii against CCl4 induced Liver Damage in Wistar Rats. American Journal of Food and Nutrition. 2017; 5(4):121-125. doi: 10.12691/ajfn-5-4-2.

Correspondence to: R.  Subramanian, Department of Chemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Tamilnadu, India. Email: subu_m1@yahoo.com

Abstract

The aim of the present study was to evaluate the antioxidant potential of the stem bark extract of Shorea roxburghii (S. roxburghii) on CCl4 induced liver toxicity. Stem bark extract of Shorea roxburghii (SRE) was prepared using ethyl acetate. Administration of S. roxburghii inhibited the elevation marker enzymes such as aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) and liver lipid peroxides in CCl4-treated Wistar rats. The natural antioxidant enzymes such catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and lipid peroxidation were significantly improved after the treatment of S.roxburghii. In this study, the results indicate that S.roxburghii can inhibit lipid peroxidation and improve the activities of antioxidant enzymes. The quantitative analysis of biochemical parameters, marker enzymes, antioxidant activities and histological study suggest the administration of the stem bark extract of S.roxburghii protecting the liver from CCl4 toxicity.

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