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B.H. Wang, K.A. Zuzel, K. Rahman, “Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices”. Toxicology. Vol. 132, no. 2-3, pp. 215-225, 1999.

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Article

Garlic Induced Apoptosis, Cell Cycle Check Points and Inhibition of Cancer Cell Proliferation

1Department of Zoology, D. D.U. Gorakhpur University, Gorakhpur, 273009.U.P. India


Journal of Cancer Research and Treatment. 2017, Vol. 5 No. 2, 35-54
DOI: 10.12691/jcrt-5-2-2
Copyright © 2017 Science and Education Publishing

Cite this paper:
Ravi Kant Upadhyay. Garlic Induced Apoptosis, Cell Cycle Check Points and Inhibition of Cancer Cell Proliferation. Journal of Cancer Research and Treatment. 2017; 5(2):35-54. doi: 10.12691/jcrt-5-2-2.

Correspondence to: Ravi  Kant Upadhyay, Department of Zoology, D. D.U. Gorakhpur University, Gorakhpur, 273009.U.P. India. Email: rkupadhya@yahoo.com

Abstract

Present review article describing effects of garlic components on induction of apoptosis, cell cycle check points and inhibition of cancer cell proliferation. Garlic derived organic compounds hold unique therapeutic potential and induces apoptotic signaling pathways; do cell cycle arrest, and show cytotoxic and anti-invasive activity to a variety of cancer cells. Regular dietary intake of garlic cut down neoplastic growth, cancer cell proliferation, and induces programmed cell death. Garlic components act as tumor suppressor agents and prevent aberrant cell expansion by slowing down the cell cycle, or by inducing apoptosis. These apoptosis inducers can act on various apoptosis-related proteins to promote apoptotic cell death. Garlic based nanoformulations can target oncogenic mutations which disrupt apoptosis. These can inhibit cellular changes leading to tumor initiation, progression of metastasis. Garlic derivatives can control DNA damage thereby slow down oncogenic changes and induce caspase activity which halts or stalls mutation in p53 gene and thereby stops growth of lung, colon, and breast cancer. More often, new combinations of garlic components may stop cancer progression as well as multistage carcinogenesis. No doubt garlic components can be used in designing best possible molecular targets of cancer cells and that could be recommended for clinical management of different types of cancer.

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