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G. N. George, R. C. Prince, J. Gailer, G. A. Buttigieg, M. B. Denton, H. H. Harris, I. J. Pickering, Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury, Chem. Res. in Tox., 17(8), 999-1006 (2004).

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Article

The Inhibition and Reactivation of Enzymatic Processes

1University of Education Ludwigsburg, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany


World Journal of Chemical Education. 2017, Vol. 5 No. 3, 102-106
DOI: 10.12691/wjce-5-3-4
Copyright © 2017 Science and Education Publishing

Cite this paper:
A. Habekost. The Inhibition and Reactivation of Enzymatic Processes. World Journal of Chemical Education. 2017; 5(3):102-106. doi: 10.12691/wjce-5-3-4.

Correspondence to: A.  Habekost, University of Education Ludwigsburg, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany. Email: A.Habekost@t-online.de

Abstract

We present experiments that show the inhibition of the catalytic activity of the enzyme urease on the chemical degradation of urea with copper ions. In addition, we demonstrate the efficiency of the antidotes 2,3-dimercapto-1-propanesulfonic acid (DMPS, 2,3-bis(sulfanyl)propane-1-sulfonic acid) and 2,5-dimercapto-1,3,4-thiadiazole (DMTD) on reactivation of urease by complexation of copper.

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