1Department of Pharmacology, Medical School of Akdeniz University, Antalya, Turkey
2Department of Biochemistry, Research and Training Hospital, Antalya, Turkey
3Department of Haematology, Research and Training Hospital, Antalya, Turkey
Journal of Food and Nutrition Research.
2016,
Vol. 4 No. 3, 148-151
DOI: 10.12691/jfnr-4-3-3
Copyright © 2016 Science and Education PublishingCite this paper: Coşkun Usta, Aslı Bedel, Ayşegül Uğur Kurtoğlu, Erdal Kurtoğlu. Effects of Crabapple (
Malus sylvestris) on Blood Glucose and Lipid Levels in Diabetic Rats.
Journal of Food and Nutrition Research. 2016; 4(3):148-151. doi: 10.12691/jfnr-4-3-3.
Correspondence to: Coşkun Usta, Department of Pharmacology, Medical School of Akdeniz University, Antalya, Turkey. Email:
fcusta@akdeniz.edu.trAbstract
We aimed to investigate the impact of crabapple on blood glucose and lipids levels in the streptozotocin (STZ)-induced diabetic rats. Rats were divided into 3 groups. The first group was control; the second group was diabetic rats while the third group was diabetic rats fed with crabapple (2 g/day). Diabetes was induced by STZ. After 6 weeks of experimental period blood samples were collected from the abdominal aorta under anaesthesia and lipid parameters were measured with auto-analyzer. However, there was significant increase both in blood glucose and lipid levels of untreated diabetes group. Likewise, blood triglyceride levels were found to be significantly reduced in the diabetic group fed with crabapple compared with untreated diabetic animals. This is the first study that approves blood glucose and triglyceride lowering effects of crabapple after six weeks supplementation. However, the underlying mechanisms of this action remain to be investigated later.
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