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K. Nakamoto. In Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B, 6th ed., John Wiley and Sons, Inc., USA, (2009).

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Article

Synthesis, Characterization and Antifungal Activity of Some Metal Complexes Derived From Quinoxaloylhydrazone

1Department of Chemistry, Sultan Qaboos University, Muscat, Sultanate of Oman

2Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy

3Department of Chemistry, Al al-Bayt University, Mafraq, Jordan

4Clinical Pharmacy, Al-Baha University, Al Baha, Saudi Arabia

5Department of Chemistry, Al-Baha University, Al Baha, Saudi Arabia

6Faculty of Pharmacy & Medical Science, Hebron University, Hebron, Palestine


World Journal of Organic Chemistry. 2015, Vol. 3 No. 1, 1-8
DOI: 10.12691/wjoc-3-1-1
Copyright © 2015 Science and Education Publishing

Cite this paper:
Ahmed Mahal, Rajab Abu-El-Halawa, Sami A. Zabin, Mohammad Ibrahim, Mahmoud Al-Refai, Tawfeq Kaimari. Synthesis, Characterization and Antifungal Activity of Some Metal Complexes Derived From Quinoxaloylhydrazone. World Journal of Organic Chemistry. 2015; 3(1):1-8. doi: 10.12691/wjoc-3-1-1.

Correspondence to: Rajab  Abu-El-Halawa, Department of Chemistry, Al al-Bayt University, Mafraq, Jordan. Email: ahmed.salem@unina.it; halawarajab@yahoo.com

Abstract

New Complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and Tin(II) with 3-methyl-2-(pyridine-2-yl-methylene-hydrazinocarbonyl)quinoxaline-4-oxide (LHP) and 2-(2-hydroxy benzylidene-hydrazinocarbonyl)-3-methylquinoxaline-4-oxide (LHS) were prepared. The new complexes were characterized by elemental analysis, conductivity, magnetic measurements, IR and UV-Vis spectroscopic measurements. The results indicate 1:1 [M:L] chelates with the general formula [M(LHP)Cl2].nH2O where: M = Mn(II), n=4, Co(II), n=1/2, Cu(II), n=1, Hg(II), n=1, and 1:2 [M:L] in case of [M(LHS)2](OAc)2.nH2O when M = Zn(II), n= 3, Cd(II), n= 1, Hg(II), n= 1/2. The tin complex structure is suggested to be [Sn(LHP)2]Cl2.2H2O, while copper produces [Cu2(LHS)2SO4].H2O complexes. Also, the formula for mercuric complex found to be [Hg(LHS)2Cl2].2H2O. The magnetic moment measurements and electronic spectra suggest octahedral geometry for the prepared complexes. The antifungal investigation reveals that the activity was enhanced by chelation. The Cu(II) complexes has the highest inhibition zone against A. niger. But, the antifungal activity was weaker than the standard drug used.

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