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Pluznick, J.L., Zou, D.J., Zhang, X., Yan, Q., Rodriguesz-Gil, D.J., Eisner, C., Wells, E., Greer, C.A., Wang, T., Firestein, S., Schnermann, J., Caplan, M.J., “Functional expression of the olfactory signaling system in the kidney”, Proceedings of the National Academy of Sciences of the United States of America, 106 (6), 2059-2064, 2009.

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Article

Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells

1Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea


Journal of Food and Nutrition Research. 2014, Vol. 2 No. 11, 776-780
DOI: 10.12691/jfnr-2-11-3
Copyright © 2014 Science and Education Publishing

Cite this paper:
Yeo Cho Yoon, Sung-Hee Kim, Jin-Taek Hwang, Mi Jeong Sung, Myung-Sunny Kim, Haeng Jeon Hur, Mee Ra Rhyu, Jae-Ho Park. Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells. Journal of Food and Nutrition Research. 2014; 2(11):776-780. doi: 10.12691/jfnr-2-11-3.

Correspondence to: Jae-Ho  Park, Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea. Email: jaehoparkmail@gmail.com

Abstract

Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca2+ and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca2+. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway.

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