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Article

Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors

1Department of the Molecular Biology of Cancer, Institute of Experimental Medicine AS CR, Prague, Czech Republic

2Institute of Biology and Medical Genetics, First Faculty of Medicine Charles University, Prague, Czech Republic


International Journal of Celiac Disease. 2014, Vol. 2 No. 3, 93-96
DOI: 10.12691/ijcd-2-3-6
Copyright © 2014 Science and Education Publishing

Cite this paper:
Pavel Procházka. Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors. International Journal of Celiac Disease. 2014; 2(3):93-96. doi: 10.12691/ijcd-2-3-6.

Correspondence to: Pavel  Procházka, Department of the Molecular Biology of Cancer, Institute of Experimental Medicine AS CR, Prague, Czech Republic. Email: proch.pavel@gmail.com

Abstract

Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with CTNNB1, VHL, CDKN2A, KRAS, TP53, RNF43, SMAD4, GNAS, PRSS1, ATM, BRCA1, BRCA2, PALB2, STK11 and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases.

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