Article citationsMore >>

Dubois, P. C.; Trynka, G.; Franke, L.; Hunt, K. A.; Romanos, J.; Curtotti, A.; Zhernakova, A.; Heap, G. A.; Adány, R.; Aromaa, A.; Bardella, M. T.; van den Berg, L. H.; Bockett, N. A.; de la Concha, E. G.; Dema, B.; Fehrmann, R. S.; Fernández-Arquero, M.; Fiatal, S.; Grandone, E.; Green, P. M.; Groen, H. J.; Gwilliam, R.; Houwen, R. H.; Hunt, S. E.; Kaukinen, K.; Kelleher, D.; Korponay-Szabo, I.; Kurppa, K.; MacMathuna, P.; Mäki, M.; Mazzilli, M. C.; McCann, O. T.; Mearin, M. L.; Mein, C. A.; Mirza, M. M.; Mistry, V.; Mora, B.; Morley, K. I.; Mulder, C. J.; Murray, J. A.; Núñez, C.; Oosterom, E.; Ophoff, R. A.; Polanco, I.; Peltonen, L.; Platteel, M.; Rybak, A.; Salomaa, V.; Schweizer, J. J.; Sperandeo, M. P.; Tack, G. J.; Turner, G.; Veldink, J. H.; Verbeek, W. H.; Weersma, R. K.; Wolters, V. M.; Urcelay, E.; Cukrowska, B.; Greco, L.; Neuhausen, S. L.; McManus, R.; Barisani, D.; Deloukas, P.; Barrett, J. C.; Saavalainen, P.; Wijmenga, C.; van Heel, D. A., Multiple common variants for celiac disease influenci

Article

Role of PARK7/DJ-1 in Gastrointestinal Diseases

Domonkos Pap^{1, 2}, Apor Veres-Székely^{1, 2}, Beáta Szebeni^{1, 2}, Zrufkó Réka^{1, 2}, Péter Bokrossy^{1, 2}, Csenge Szász^{1, 2}, Ádám Vannay^{1, 2,}

¹Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary

²HUN-REN-SE Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary

International Journal of Celiac Disease. 2024, Vol. 12 No. 1, 28-32
DOI: 10.12691/ijcd-12-1-6
Copyright © 2024 Science and Education Publishing

Cite this paper:
Domonkos Pap, Apor Veres-Székely, Beáta Szebeni, Zrufkó Réka, Péter Bokrossy, Csenge Szász, Ádám Vannay. Role of PARK7/DJ-1 in Gastrointestinal Diseases. International Journal of Celiac Disease. 2024; 12(1):28-32. doi: 10.12691/ijcd-12-1-6.

Correspondence to: Ádám  Vannay, Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary. Email: vannay.adam@semmelweis.hu

Abstract

Parkinson’s disease 7 (PARK7/DJ-1) is an evolutionarily conserved multifunctional protein whose role has been widely demonstrated in malignant tumours and neurodegenerative diseases, including Parkinson's or Alzheimer's disease. However, recent studies also revealed protective role of PARK7/DJ-1 regarding gastrointestinal diseases. In the present review, we discuss our current knowledge about PARK7/DJ-1 in the context of coeliac and inflammatory bowel disease.

Keywords

PARK7/DJ-1, coeliac disease, inflammatory bowel disease, Crohn’s disease, ulcerative colitis