1Department of Plant Biology & Plant Biotechnology, S.D.N.B. Vaishnav College for Women, Chennai, India
Applied Ecology and Environmental Sciences.
2022,
Vol. 10 No. 8, 534-539
DOI: 10.12691/aees-10-8-6
Copyright © 2022 Science and Education PublishingCite this paper: Sugandhi S, Rani G. Anti-cancer Effect of Gold Nanoparticles of
Gracilaria sp. against HeLa and MCF-7 Cell Lines.
Applied Ecology and Environmental Sciences. 2022; 10(8):534-539. doi: 10.12691/aees-10-8-6.
Correspondence to: Rani G, Department of Plant Biology & Plant Biotechnology, S.D.N.B. Vaishnav College for Women, Chennai, India. Email:
ranvenshre@gmail.comAbstract
The main objective of this study was to examine the anticancer activities of the gold nanoparticles of marine seaweeds viz., Gracilaria verrucosa, G. pudumadamensis and G. salicornia. Gold nanoparticles of the three species of Gracilaria were tested for their anticancer properties in vitro against HeLa and MCF-7 cancer cell lines. HeLa cell line is cervical cancer cells and MCF-7 is breast cancer cells. The anticancer activity of gold nanoparticles of the seaweed was observed based on cell viability and morphology of the treated cells and control. Among the three species, G. verrucosa showed a greater activity with an IC 49.80 against HeLa than the other two species. While greater anticancerous activity was observed in G. salicornia with IC 49.69 against MCF-7 cell line. The morphology of the treated cells showed a great variation when compared to the control cells. Thus, the in vitro assay indicated that the gold nanoparticles synthesized by these red seaweeds are the significant source of a noble anticancer agent. The study also revealed that G. verrucosa, G. pudumadamensis and G. salicornia could be the promising bioagents for cancer therapy in the near future.
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