Zhou Xin^1,, Lin Tong¹, Zhang Qingye¹, Zhao Xia¹

Purpose: To observe the relationship between the level of glycosylated hemoglobin (HbA1c) during pregnancy and the incidence of gestational diabetes mellitus (GDM) and the outcome of pregnancy in GDM patients. Methods: There were 334 pregnant women with GDM and 366 pregnant women with normal blood glucose selected into our research who had undergone regular check-ups and deliveries in our hospital from October 2018 to October 2019. Results: (1) Pregnant women with overweight and obesity before pregnancy have higher HbA1c in the first and third trimesters than those with normal and low weight before pregnancy (P<0.05). And the pregnancy of excessive weight gain during the second and third trimester and the total weight excessive gain pregnancy were statistically significant in HbA1c of third trimesters (P<0.05). (2) HbA1c in early pregnancy is a risk factor for the onset of GDM (OR=4.591, 95%CI 2.504-8.418). And the prediction critical point of GDM prediction of HbA1c in early pregnancy is 5.25%. (3) Logistic multivariate regression analysis found that HbA1c in the third trimester of pregnancy was the risk factor of adverse outcome of pregnancy including hypertensive disorders of pregnancy (OR=3.997, 95%CI 1.697-9.411), cesarean section (OR=2.024, 95%CI 1.179-3.474), and macrosomia (OR=2.261, 95%CI 1.198-4.267). Conclusion: The detection of HbA1c in early pregnancy helps to screen high-risk pregnancy of GDM and intervene them earlily. And HbA1c in the third trimester can help predict adverse pregnancy outcomes.

glycosylated hemoglobin, gestational diabetes mellitus, adverse pregnancy outcome