1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria
2Department of Animal Production and Health, Faculty of Agriculture, Federal University, Oye, Oye-ekiti, Ekiti State, Nigeria
3Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
American Journal of Pharmacological Sciences.
2014,
Vol. 2 No. 1, 24-26
DOI: 10.12691/ajps-2-1-5
Copyright © 2014 Science and Education PublishingCite this paper: Nwaehujor Chinaka O, Asuzu Onyeka V, Asuzu Isaac U. Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol.
American Journal of Pharmacological Sciences. 2014; 2(1):24-26. doi: 10.12691/ajps-2-1-5.
Correspondence to: Nwaehujor Chinaka O, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria. Email:
chinaka_n@yahoo.comAbstract
D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for membrane stabilizing potentials in red blood cells of alloxan-induced diabetic albino Swiss mice. Blood from diabetic animals treated with different doses of the compound (8, 4, 2 mg/kg) and Glibenclamide (2 mg/kg) were measured for membrane stability at different saline concentrations. The MCF values and their corresponding percentage stabilization were increased in the treatment groups compared to the negative control. The result suggests that D-3-O-methylchiroinositol possesses membrane stabilizing potentials.
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