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Article

Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review

1Nephrology Department, Shifa International Hospital, Islamabad, 00000, Pakistan


American Journal of Medical Case Reports. 2021, Vol. 9 No. 12, 725-729
DOI: 10.12691/ajmcr-9-12-17
Copyright © 2021 Science and Education Publishing

Cite this paper:
Nida Saleem, Saima Bashir, Syed Nayer Mahmud, Muhammad Haneef. Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review. American Journal of Medical Case Reports. 2021; 9(12):725-729. doi: 10.12691/ajmcr-9-12-17.

Correspondence to: Nida  Saleem, Nephrology Department, Shifa International Hospital, Islamabad, 00000, Pakistan. Email: nidasaa1968@gmail.com

Abstract

We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

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