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Shi J, Guan J, Jiang B, et al. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A 2010; 107: 4188.

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Article

Hiccups as an Atypical Presentation of Complete Heart Block and Cardiac Amyloidosis with Multiple Myeloma

1Department of Internal Medicine, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ, USA 07039

2Department of Internal Medicine, Hemet Global Medical Center, 1117 East Devonshire Avenue, Hemet, CA, USA 92543


American Journal of Cardiovascular Disease Research. 2021, Vol. 7 No. 1, 1-3
DOI: 10.12691/ajcdr-7-1-1
Copyright © 2021 Science and Education Publishing

Cite this paper:
Paarth Shah, Ankit Dubey. Hiccups as an Atypical Presentation of Complete Heart Block and Cardiac Amyloidosis with Multiple Myeloma. American Journal of Cardiovascular Disease Research. 2021; 7(1):1-3. doi: 10.12691/ajcdr-7-1-1.

Correspondence to: Ankit  Dubey, Department of Internal Medicine, Hemet Global Medical Center, 1117 East Devonshire Avenue, Hemet, CA, USA 92543. Email: ankit.dubey@phh.ms

Abstract

Cardiac amyloidosis typically causes heart failure due to restrictive cardiomyopathy. Along with structural defects, cardiac amyloidosis can also cause conduction abnormalities, especially bradyarrhythmias. When suspected, cardiac amyloidosis can be diagnosed via cardiac imaging modalities or biopsy. However, due to various atypical patient presentations, diagnosing cardiac amyloidosis requires a high index of suspicion and can often be cryptic in nature. We present the rare case of a 71-year-old male who presented with hiccups as his primary symptom and was found to have complete heart block in the setting of cardiac amyloidosis from multiple myeloma in the absence of restrictive cardiomyopathy.

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