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Ruebush TK 2nd, Chisholm ES, Sulzer AJ, Healy GR. Development and persistence of antibody in persons infected with Babesia microti. Am J Trop Med Hyg. 1981; 30(1): 291-292.

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Differential Diagnosis in the Age of COVID-19 and the Need to Maintain a Broad Differential

1Lenox Hill Hospital, Department of Internal Medicine New York, NY

American Journal of Medical Case Reports. 2021, Vol. 9 No. 1, 62-64
DOI: 10.12691/ajmcr-9-1-15
Copyright © 2020 Science and Education Publishing

Cite this paper:
Amandeep S. Saini, Jacob Schwartz. Differential Diagnosis in the Age of COVID-19 and the Need to Maintain a Broad Differential. American Journal of Medical Case Reports. 2021; 9(1):62-64. doi: 10.12691/ajmcr-9-1-15.

Correspondence to: Jacob  Schwartz, Lenox Hill Hospital, Department of Internal Medicine New York, NY. Email:


During the coronavirus pandemic, patients admitted to emergency departments (ED) with constitutional symptoms, respiratory complaints, and/or history of sick contacts have high clinical suspicion for COVID-19 regardless of whether initial screening tests are negative. Although communities seek daily coronavirus infection rates of less than one percent, physicians can be highly focused on narrow differentials despite adequate history and physical exams. This case report focuses on an elderly patient with a past medical history of hypertension, chronic kidney disease (CKD), and gout who presented with three days of fevers, chills, body aches, and shortness of breath and reported a home oxygen saturation of 89%. The patient was a health care worker with high risk of contracting COVID-19, and on admission was febrile and found to have lymphopenia. Nevertheless, COVID-19 Polymerase Chain Reaction (PCR) testing returned negative on two separate occasions prompting the team to broaden their differential. Leukopenia, thrombocytopenia and mildly elevated transaminases can all be due to COVID-19, but should also lead medical teams to include tick-borne illnesses as a potential etiology. Parasite serology returned positive for Babesia microti via IgG antibodies (1:512) and Anaplasma phagocytophilum via PCR and the patient was discharged on appropriate antimicrobial therapy. It is important for providers to understand and recognize the following: 1) overlapping symptoms of tick-borne disease and COVID-19, 2) proper diagnosis and management of babesiosis and anaplasmosis, and 3) benefits of broad differentials for patient care during the COVID-19 pandemic.