Morsy A. Aboelgoud^1,, Ahmad M. Alessi², Ahmad M.Ihab³

Background: Diabetes mellitus is an unpredictable issue that is portrayed by hyperglycemia coming about because of breakdown in insulin discharge and activity. As of late curcumin extract have been reported to be useful in treatment of type II diabetes. Aim of the work: In this research curcumin extract was used instead of chemical drugs for the treatment of diabetes mellitus. Material and methods: 30 male adult albino rats aged 5-7 months and their average weight was 150-200 grams were divided into three groups. The first one (n=10) control group, the second group (n=10) was injected with a single dose of alloxan (42 mg/kg). The third group (n=10) was injected with alloxan and after 3 days was received curcumin extract orally 80mg/kgm daily for one month. The rats were scarified after the last dose of the drug and their pancreases were removed, fixed and different sections were prepared and stained for light microscope study. Results: After induction of diabetes the islets of Langerhans revealed architectural disarray. The islets cells showed atrophy in size with cellular necrobiosis associated with cystic dilatation and luminal eosinophilic casts. The intensity anti-insulin antibody reaction was decreased. So donation of curcumin extract reduced the islets cells damage and increase in the intensity of anti-insulin antibody reaction. Conclusion: The present study revealed that curcumin extract has potential effect in treatment of type II diabetes.

pancreas, islets of Langerhans, diabetes mellitus, Alloxan, curcumin extract, white rats