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American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing; 2013

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Unintentional Drowning Associated with Multiple Cerebral Cavernous Malformations

1Department of Pediatrics, Saiseikai Toyama Hospital

2Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital

3Department of Pediatrics, Faculty of Medicine, University of Toyama

American Journal of Medical Case Reports. 2019, Vol. 7 No. 9, 217-218
DOI: 10.12691/ajmcr-7-9-9
Copyright © 2019 Science and Education Publishing

Cite this paper:
Hiro Matsukura, Satomi Inomata, Tomomi Tanaka. Unintentional Drowning Associated with Multiple Cerebral Cavernous Malformations. American Journal of Medical Case Reports. 2019; 7(9):217-218. doi: 10.12691/ajmcr-7-9-9.

Correspondence to: Hiro  Matsukura, Department of Pediatrics, Saiseikai Toyama Hospital. Email:


Cerebral cavernous malformations (CCMs), which occur in a sporadic or familial form, can predispose a person to seizures, focal neurological impairment, and hemorrhage. Upon discovery floating in a swimming pool, a 3-year-old boy was unresponsive and not breathing, but he achieved uneventful recovery after adequate cardiopulmonary resuscitation. Diagnostic head magnetic resonance imaging confirmed multiple CCMs. Absence of affected family members was indicative of the sporadic form. Subsequently, he developed social communication deficits and restricted and repetitive behaviors, suggestive of autism spectrum disorders (ASD). Comorbidity of CCMs and ASD is rare. Seizure associated with multiple CCMs might precipitate unintentional drowning.