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Ma J, Jesudason DR, Stevens JE et al. Sustained effects of a protein 'preload' on glycaemia and gastric emptying over 4 weeks in patients with type 2 diabetes: A randomized clinical trial. Diabetes Res Clin Pract. 2015 May; 108 (2).

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Article

Macronutrient Preload effect on Glycaemic Control and Pregnancy Outcome in Gestational Diabetes Mellitus

1Department of Clinical Nutrition, Peking University People’s Hospital, Beijing, China

2Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden


Journal of Food and Nutrition Research. 2018, Vol. 6 No. 9, 584-589
DOI: 10.12691/jfnr-6-9-7
Copyright © 2018 Science and Education Publishing

Cite this paper:
Cai Jingjing, Lv Jing, Guo Qianying, Wang Boshi, Gunnar Norstedt, Magnus Sederholm, Liu Peng. Macronutrient Preload effect on Glycaemic Control and Pregnancy Outcome in Gestational Diabetes Mellitus. Journal of Food and Nutrition Research. 2018; 6(9):584-589. doi: 10.12691/jfnr-6-9-7.

Correspondence to: Liu  Peng, Department of Clinical Nutrition, Peking University People’s Hospital, Beijing, China. Email: liupengpku@163.com

Abstract

Objective: To investigate the effect of macronutrient preload treatment, MPT, on glycemic control and pregnancy outcome in gestational diabetes mellitus, GDM. Study Design: 40 patients with GDM were randomized to either MPT in addition to health education and dietary guidance (n=25) or health education and dietary guidance only (n=15). MPT was given three times/day, 30 minutes before regular meals and continued until term. Participants were subjected physical examination, laboratory analysis and pregnancy outcomes. Results: The time until the participant reached stable euglycemia was shorter in the preload group compared to controls (P<0.05), in patients ≥30 years old (1.3±0.55 versus 2.5±1.1 weeks, P<0.05), in pre-gestational BMI<24 kg/m2 (1.3±0.58 versus 1.9±0.69 weeks, P<0.05) and in pre-gestational BMI≥24 kg/m2 (1.2±0.44 versus 2.6±1.32 weeks, P<0.05). The birth weight in the subgroup of BMI>24 kg/m2 was lower in the MTP group compared to the control group (3124±523g versus 3780.0±472g, P<0.05). Increase of HbA1c ≥5% was significantly lower after preload treatment. Conclusion; MPT can safely be used in patients with gestational diabetes mellitus for effective control of blood glucose. The significant reduction of birth weight in participants with pre-gestational BMI ≥24kg/m2 indicates that preload can be used to control negative effects of hyperglycemia, with reduced risk for complications during delivery.

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