Rika Handayani¹, Tahir Abdullah², Furqaan Naiem³, Anwar Mallongi⁴, Rahmat Haji Saeni⁵, Ekayanti Hafidah Ahmad⁶, Prihantono Prihantono^7,

Background. Operating room is one of the many workplace hazards. In the operating room nurses and other health personnel at risk of exposure to chemicals. One type of inhalation anesthetic gas that is isoflurane (foran, aeran). Isoflurane a halogenated hydrocarbon compounds volatile ether. Exposure to halogenated anesthetic gases can result in effects on reproductive health. Method. The study design used is Retrospective cohort, with a sample size of 16 exposed and 16 unexposed. Mechanical sampling random sampling. Data analysis used independent t-test. Results. The results showed that exposure status isoflurane effect on fertility disorder where there are differences in average significantly between hormone gene expression estrogen the exposed group (9.35 ± 1.78) and unexposed (11.65 ± 1.44) with values p = 0.013 (p < 0.05). The tenure of the effect on fertility disorder where there are differences in average significantly between the tenure of the hormone gene expression estrogen namely the working period of 5-9 years (11.84 ± 1.16) and ≥10 years (8.52 ± 0.94) with values p = 0.006 ( p < 0.05). Hormone gene expression estrogen effect on fertility disorder where there are differences in average significantly between hormone gene expression estrogen against fertility disorder that nurses are experiencing hormonal changes in gene expression estrogen risk of impaired fertility (8.52 ± 0.94) and that did not change hormone gene expression estrogen not at risk of reduced fertility (11.69 ± 1.33) with values p = < 0.001 (p < 0.05). Conclusion: Based on this it is expected that the Health and Safety at Work Hospital perform periodic monitoring the work environment primarily in the operating room.

exposure status isoflurane, work period, hormone gene expression estrogen and fertility disorders