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Sakallioglu EE, Aliyev E, Lutfioglu M, Yavuz U, Acikgoz G. Vascular endothelial growth factor (VEGF) levels of gingiva and gingival crevicular fluid in diabetic and systemically healthy periodontitis patients. Clin Oral Investig Clin Oral Investig. 2007 Jun; 11(2): 115-20.

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Effect of Vascular Endothelial Growth Factor Expression in the Destruction and Healing Stages of Chronic Periodontal Disease: A Case Report

1Periodontology and Oral Medicine Department, Qassim College of Dentistry, Qassim University, Saudi Arabia


International Journal of Dental Sciences and Research. 2017, Vol. 5 No. 2, 35-38
DOI: 10.12691/ijdsr-5-2-5
Copyright © 2017 Science and Education Publishing

Cite this paper:
Alaa Abdelhamid. Effect of Vascular Endothelial Growth Factor Expression in the Destruction and Healing Stages of Chronic Periodontal Disease: A Case Report. International Journal of Dental Sciences and Research. 2017; 5(2):35-38. doi: 10.12691/ijdsr-5-2-5.

Correspondence to: Alaa  Abdelhamid, Periodontology and Oral Medicine Department, Qassim College of Dentistry, Qassim University, Saudi Arabia. Email: dr.alaa.abdelhamid@qudent.edu.sa

Abstract

Vascular endothelial growth factor (VEGF) is a homodynamic protein produced by different cells as endothelial cells, macrophages, T-cells. In epithelial and endothelial cells, VEGF has been reported more in periodontitis than in sites with gingivitis, suggesting that it could be a crucial factor for the initiation of gingivitis and its transition to periodontitis. Objective: To determine the effect of non-surgical periodontal treatment on VEGF expression on gingival tissues with chronic periodontitis. Methods: Gingival samples (2-3 mm) were collected immediately before and 4 weeks after non-surgical periodontal therapy from a 48-year-old male with chronic periodontitis. The samples were treated with immunohistochemically. Results: A decrease in VEGF expression was observed in gingival tissues following non-surgical periodontal treatment. Conclusion: VEGF is continually produced and expressed in healthy and diseased gingival tissues; non-surgical periodontal therapy with antibiotics combination significantly affects the expression pattern of VEGF as a biomarker.

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