Vascular endothelial growth factor (VEGF) is a homodynamic protein produced by different cells as endothelial cells, macrophages, T-cells. In epithelial and endothelial cells, VEGF has been reported more in periodontitis than in sites with gingivitis, suggesting that it could be a crucial factor for the initiation of gingivitis and its transition to periodontitis. Objective: To determine the effect of non-surgical periodontal treatment on VEGF expression on gingival tissues with chronic periodontitis. Methods: Gingival samples (2-3 mm) were collected immediately before and 4 weeks after non-surgical periodontal therapy from a 48-year-old male with chronic periodontitis. The samples were treated with immunohistochemically. Results: A decrease in VEGF expression was observed in gingival tissues following non-surgical periodontal treatment. Conclusion: VEGF is continually produced and expressed in healthy and diseased gingival tissues; non-surgical periodontal therapy with antibiotics combination significantly affects the expression pattern of VEGF as a biomarker.

chronic periodontitis, non-surgical periodontal therapy, vascular endothelial growth factor