This study on Academic staff perception of Quality of Work-Life and University Goal Attainment was designed to have some understanding of the QWL of university academic staff and to relate this understanding to their performance towards university goal attainment in the South-South geo Political Zone of Nigeria. The topic was chosen because of persistent complaints concerning the low quality of university output in Nigeria for over a decade. Two research questions and two null hypotheses were raised to examine the QWL of university academic staff, university goal attainment and the relationship between the two variables. The significance of the study is to help those involved in higher educational planning, policy formulation and implementation to achieve optimum university outcomes through performance and QWL of academic staff. The study was guided by a theoretical concept on self-theory with a plethora of self-based theories on QWL and university goal attainment. The review indicated that only very limited work had been done in this area in Nigeria, on university and on the subjects. The sample constituted 1681 of university academic staff and this was 36% of the entire population of academic staff in the zone. Two questionnaires were each developed for QWL and UGA respectively in addition to personal interviews and document review. Results of the study revealed a state of satisfactory QWL for the staff; a state of unfavourable University goal attainment; and insignificant relationship between QWL and UGA in the universities. These results are unique in the sense that they revealed that satisfactory QWL of university academic staff does not generate commensurate satisfactory UGA in the Zone in Nigeria.