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Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972; 29(3): 670-683.

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Article

Unicentric Mixed Variant Castleman Disease Associated with Brachiocephalic Vein Thrombosis: A Rare Presentation

1Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

2Department of Diagnostic Pathology, University hospital of Charles Nicolle, Tunis, Tunisia

3Department of Radiology, University hospital of Charles Nicolle, Tunis, Tunisia


American Journal of Medical Case Reports. 2016, Vol. 4 No. 10, 339-342
DOI: 10.12691/ajmcr-4-10-3
Copyright © 2016 Science and Education Publishing

Cite this paper:
Imene Boukhris, Hana Zoubaidi, Ines Kechaou, Eya Cherif, Nadia Znaidi, Aicha Ben Miled, Narjes Khalfallah. Unicentric Mixed Variant Castleman Disease Associated with Brachiocephalic Vein Thrombosis: A Rare Presentation. American Journal of Medical Case Reports. 2016; 4(10):339-342. doi: 10.12691/ajmcr-4-10-3.

Correspondence to: Imene  Boukhris, Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia. Email: imen.boukhris@laposte.net

Abstract

Castleman disease (CD) is an uncommon lymphoproliferative disorder occurring mostly in patients presenting with mediastinal lymphadenopathy. Predominant phenotypes are categorized as localized hyaline vascular or multicentric plasma cell variants. Localized form of CD is usually asymptomatic and rarely associated with deep venous thrombosis. We report an exceptional case of mediastinal CD, which presented as retrosternal chest pain, in a 42-year old man. Imaging and pathological examination showed an atypical, mixed and localized form of CD. Thoracic CT scan revealed brachiocephalic vein thrombosis. Investigations didn’t reveal other risk factors for deep venous thrombosis. Deep venous thrombosis is an exceptional complication of localized variants of CD. Therefore, it seems worth looking carefully for this last type of benign lymphopathy when an unusual thrombosis is found.

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