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Aebi, H., “Catalase in vivo”, Methods Enzymol, 105.121-126.1984.

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Article

Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen

1Biochemistry and Molecular Biology laboratory, Ain Chock Faculty of Science Hassan II University, Casablanca, Morocco

2Microbiology pharmacology Biotechnology and Environment laboratory, Ain Chock Faculty of Science Hassan II University, Casablanca, Morocco


American Journal of Biomedical Research. 2013, Vol. 1 No. 4, 75-79
DOI: 10.12691/ajbr-1-4-2
Copyright © 2013 Science and Education Publishing

Cite this paper:
BENKHASSI Zoubair, LAHLOU Fatima Azzahra, HMIMID Fouzia, LOUTFI Mohammed, BENAJI Brahim, BOURHIM Noureddine. Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen. American Journal of Biomedical Research. 2013; 1(4):75-79. doi: 10.12691/ajbr-1-4-2.

Correspondence to: LAHLOU Fatima Azzahra, Biochemistry and Molecular Biology laboratory, Ain Chock Faculty of Science Hassan II University, Casablanca, Morocco. Email: lahloufz@hotmail.fr

Abstract

Acetaminophen (Paracetamol) is among the most commonly used analgesic and antipyretic drugs worldwide, it’s often, but anomalously, classified as non-steroidal anti-inflammatory drugs (NSAIDs) in textbooks of pharmacology . This study aims to evaluate if paracetamol has an antioxidant effect, relative to its analgesic antipyretic and weak anti-inflammatory activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection of peroxide hydrogen (H2O2), and then a comparative study is made concerning the activities of the antioxidant enzymes SOD, CAT, and GR as well as lipid peroxidation levels in liver. An increase in SOD, CAT, GR activity and lipid peroxidation in mice treated with H2O2 accompanied by paracetamol; compared to the group treated by vitamin C + H2O2 showed that acetaminophen doesn’t show any antioxidant effect. Moreover this study has suggested that acetaminophen induced cytotoxicity in liver mediated by increased oxidative stress and altered redox metabolism.

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