Sahar El Aoud¹, Nadia Charfi¹, Nessrine Cheikhrouhou¹, Mariam Kesentini², Mouna Elleuch^1,, Tahia Boudawara², Mohamed Abid¹

Cutaneous leukocytoclastic vasculitis comprises a wide spectrum of etiologies including medications. Fluoroquinolones are rarely implicated in this disease. We report the case of a diabetic man who was referred to our hospital for purpuric rash and hyperglycemia. The cutaneous lesions appeared 3 days after the begining of levofloxacin which was prescribed for a respiratory infection. Physical examination and laboratory evaluation findings ruled out renal, neurological, respiratory and gastrointestinal involvement. Skin biopsy confirmed the diagnosis of cutaneous leukocytoclastic vasculitis. Autoimmune investigations and infectious serologies were negative. Levofloxacin therapy was the most probable etiology. The patient was successfully treated by withdrawal of the offending antibiotic associated with topical steroids.

fluoroquinolones, cutaneous leukocytoclastic vasculitis, levofloxacin, purpura