Science and Education Publishing World Journal of Chemical Education 1 1 2013 08 28 Significance of Nucleophilic Solvation of Ammonium Bond (¡ÔN⁺-H) in Protonated Amines: A Thought Provoking Physical-Organic Chemistry Lecture to Graduate Students 1 5 EN R. Sanjeev V. Jagannadham Department of Chemistry, Osmania University, Hyderabad, India R. Veda Vrath WJCE2013111 10.12691/wjce-1-1-1 2013 08 13 2013 08 27 2013 08 28 Our mission has perceivedand still continuing exceptionalachievement on ¡®Transforming chemistry research in to chemistry teaching¡¯. In this course of events we have been able to publish several articles in the area of chemical education. In continuation of this,the present article using a total of 38 amines isone of our successful aftermaths of the importance of nucleophilic solvation of ammonium bond (¡ÔN⁺-H in protonated amines.We have explained the significance of nucleophilicsolvation of ammonium bond in protonated aminesin a simple and lucid way using Taft linear polar free energy correlations of pK_a¡¯sin aqueous solution and dipole moments in gas phase, in benzene, in cyclohexaneand of pure liquids of several primary, secondary and tertiary amines as a function of Taft polar substituent constants. Our performed Taft correlations showed that the solvation of ammonium bond in protonated aminesthrough ¡ÔN⁺-H bond is worth understanding in terms of steric hindrance which is absent in gas phase, in benzeneand in cyclohexane as it imparts its substance in biology.