eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2017-03-27 5 4 205 207 10.12691/jfnr-5-4-1 JFNR2017541 article Hyun Woo Kang khw7200@ysu.ac.kr 1 Department of Korean Food & Culinary Arts, Youngsan University, Busan, Korea This study was investigated to antioxidant activity in human neuronal cell lines of extract from Sophora flavescens ex Aiton (ESSA). The cell viability showed the protective effect against oxidative damage to PC12 cell by MTT assay. We show that antioxidant activities of the ESSA were evaluated using apoptosis assays analyzed by flow cytometry. ESSA decreased cell death in PC12 cells due to hydrogen peroxide-induced oxidative damage in a dose-dependent manner. In addition, ESSA regulated the expression of Bcl-2 and Bax proteins in PC-12 cells. Based on these findings, we suggest that ESSA has the potential to inhibit hydrogen peroxide-induced free radical activation and should be considered in functional food and pharmaceutical applications. http://pubs.sciepub.com/jfnr/5/4/1/jfnr-5-4-1.pdf Sophora flavescens ex Aiton antioxidant free radical neuronal cells