eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2016-09-05 4 9 596 599 10.12691/jfnr-4-9-6 JFNR2016496 article Edziri Hayet jaziri_hayet@yahoo.fr 1 Kaouthar Liouane 1 Fatma Thabti 2 Fethia Skhiri 3 Mahjoub Aouni 3 Maha Mastour 3 Laboratoire des maladies transmissibles et des substances biologiquement actives Faculté de Pharmacie-5000-Monastir- Tunisie Faculté des sciences Bizerte 7021 Zarzouna, Bizerte Laboratory of Genetic Biodiversity and Valorisation of Bioresources, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia Anticandidal, antiviral and free radical scavenging effects of aerial part and flesh extracts of Cucumis melo L. var. cantalupensis were investigated. Total phenolic content of extracts were determined using Folin-Ciocalteu method. The anticandidal activity was evaluated using microwell dilution method against four fungi. The antiviral activity was determined against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) using a cytopathic effect (CPE) reduction assay. Antiradical scavenging capacities of Cucumis melo extracts were tested using free radical forms of ABTS. Among tested extracts, aerial part extracts showed the best anticandial activity with Minimal Inhibitory Concentration (MIC) ranged from 0.256 to 2.5 mg/ml and Minimal Fungicidal Concentration (MFC) ranged from 2.5 to 5 mg/ml. In addition, such extracts exhibited the highest antiviral and antiradical activities. The results provided an evidence that the studied fruit might, indeed, be potential sources of natural antioxidant and antimicrobial agents. http://pubs.sciepub.com/jfnr/4/9/6/jfnr-4-9-6.pdf Cucumis melo L Anticandidal Antiviral ABTS Activity