@article{jfnr2015348,
author={Kang, Hyun Woo},
title={Inhibitory Effect of Cancer Cells Proliferation from Epigallocatechin-3-<i>O</i>-gallate},
journal={Journal of Food and Nutrition Research},
volume={3},
number={4},
pages={281--284},
year={2015},
url={http://pubs.sciepub.com/jfnr/3/4/8},
issn={2333-1240},
abstract={Epigallocatechin-3-<i>O</i>-gallate (EGCG), the major polyphenol of green tea and a functional food ingredient/nutraceutical with health-promoting properties. However, its anti-cancer activities on various cancer cells are still little information. Here, we show that anti-cancer activities of the EGCG were evaluated using apoptosis assays analyzed by flow cytometry. The inhibitory activities of proliferation in MPC-11, Caco-2, and MCF-7 cells, values were 66.2, 60.3, and 74.8% at 10 ¦ÌM, respectively. In addition, in an flow cytometry assay on the MPC-11, Caco-2, and MCF-7 cells, the EGCG showed a cell apoptosis effect on cancer/tomor <i>in vitro</i> model. Our results indicate that EGCG has anti-cancer activities against human lung cancer cells through inducing cell cycle arrest, DNA damage and activating mitochondrial signal pathway. These results indicate that EGCG effectively inhibits <i>in vitro</i> tumor growth by inducing apoptosis of cancer cells.},
doi={10.12691/jfnr-3-4-8}
publisher={Science and Education Publishing}
}