eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2026-03-09 14 2 45 53 10.12691/jfnr-14-2-1 JFNR20261421 article Ho-Shin Huang adinol.huang@gmail.com 1 Chi-Yu Yang 2 Pei-Chun Lin 2 Chun-Mei Lu 2 Ting-Yuan Hsu 2 3 R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan This study investigated the therapeutic potential of fermented lemon peel (FLP07) in mitigating HFD-induced NAFLD, utilizing a mouse model to compare its efficacy against the hepatoprotective agent silymarin. While HFD-fed mice exhibited significant weight gain, dyslipidemia, and intervention with FLP07 effectively improved serum triglyceride (TG) and total cholesterol (TC) levels. Furthermore, FLP07 partially restored the AST/ALT ratio and significantly reduced hepatic lipid droplet accumulation, showing comparable efficacy to silymarin. These results suggest that FLP07 is a promising natural dietary supplement for managing NAFLD and dyslipidemia. https://pubs.sciepub.com/jfnr/14/2/1/jfnr-14-2-1.pdf Gut Microbiota High-Fat Diet (HFD) Non-alcoholic Fatty Liver Disease (NAFLD) Short-Chain Fatty Acids (SCFAs)