@article{jfnr20251353,
author={{Wang, Guanqun and Baek, Ju-Hwa and Choi, Ji Myung and Choi, Hyun Seok and Ha, Ki Tae and Park, Min Jung and Joo, Bo Sun},
title={Synergistic Combination of <i>Paeonia</i><i> </i><i>Lactiflora</i> Pall with <i>Astragalus</i><i> </i><i>Membranaceus</i> for Alleviating Menopausal Symptoms in Mice},
journal={Journal of Food and Nutrition Research},
volume={13},
number={5},
pages={215--225},
year={2025},
url={https://pubs.sciepub.com/jfnr/13/5/3},
issn={2333-1240},
abstract={<i>Paeonia</i><i> </i><i>lactiflora</i> Pall (PL) with <i>Astragalus</i><i> </i><i>membranaceus</i><i> </i>(AM) are herbs widely used in traditional<b> </b>herbal medicine formulations to alleviate female menopausal symptoms. However, there are no reports on the anti-menopausal effects of a mixture of PL and AM. This study aimed to investigate whether a combination of PL with AM exerts a synergistic effect in alleviating menopausal symptoms. The mixture of PL and AM (PLAM) was combined in a ratio of 1:4, and the effect was investigated at dose of 30 and 60 mg/kg body weight (BW) in ovariectomized (OVX) mice. Six OVX groups were administered orally once a day with distilled water (10 mL/kg), estradiol valerate (0.5 mg/ kg), PL (23.5 mg/kg), AM (77 mg/kg), PLAM (30 mg/kg and 60 mg/kg) for 8 weeks, respectively. One group served as a sham-operated control. PLAM significantly decreased the body weight, uterine atrophy, and aortic intima-media thickness, while increased uterine weight, estradiol production and bone formation compared to individual extracts of PL and AM. These effects were more pronounced at a high-dose of PLAM (60 mg/kg) than a low-dose (30 mg/kg). The results demonstrate that a high-dose of PLAM mixtures exerts the best synergistic effect for alleviating menopausal symptoms in mice, suggesting that PLAM can be applied as an effective new agent for treating menopausal symptoms.},
doi={10.12691/jfnr-13-5-3}
publisher={Science and Education Publishing}
}