eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2025-03-21 13 3 140 145 10.12691/jfnr-13-3-3 JFNR20251333 article Ho-Shin Huang adinol.huang@gmail.com 1 Jyh-Perng Wang 2 Shih-Hong Chen 2 Zhe-Yu Jiang 2 Si-Ting Lin 2 Chun-Mei Lu 2 Ting-Yuan Hsu 3 Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan Animal Technology Research Center, Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan R&D Center, Kao-Ho Hospital, No. 460, Bo'ai 1st Rd., Gushan Dist, Kaohsiung City, Taiwan This study using HPLC tandem mass investigates the contents of main flavonoid compounds in fermented peel of Taiwan Citrus with Lactic acid bacteria. The results showed hesperidin, nobiletin and tangeretin were the main flavonoid compounds in fermented peel of Citrus taiwanica (FCT). In contrast, eriocitrin and hesperidin were most abundant bioactivity compounds in fermented peel of Citrus limon (FLP07). In this study, we investigated the effect of fermented citrus peel (FCT and FLP07) on Glucagon-like peptide-1(GLP-1) secretion in STC-1 cells, a well-established enteroendocrine cell model. The results showed FCT and FLP07 at all tested concentrations induced significantly higher GLP-1 secretion and suggest that FCT and FLP07 are more potent than serotonin in stimulating GLP-1 release, highlighting their potential as functional ingredients for metabolic health applications. https://pubs.sciepub.com/jfnr/13/3/3/jfnr-13-3-3.pdf fermented citrus peel flavonoid Glucagon-like peptide-1 metabolic associated fatty liver disease