@article{jfnr20251312,
author={{S, Sudhanva M and Tom, Akhina and M, Firoz H and Hussain, Zayeem Firoz and CT, Sadashiva and Rangappa, Shobith},
title={Anti-Obesity Effects of <i>Cissus</i><i> </i><i>Quadrangularis</i> (Cissuslean?) in C57bl/6j Mice with High-Fat-Diet Induced Obesity and 3t3-L1 Adipocytes},
journal={Journal of Food and Nutrition Research},
volume={13},
number={1},
pages={9--17},
year={2025},
url={https://pubs.sciepub.com/jfnr/13/1/2},
issn={2333-1240},
abstract={Obesity is gradually becoming a widespread health problem, and treatment using natural compounds has seen an increasing trend. The aim of this study investigated the effects and underlying mechanisms of <i>Cissus</i><i> </i><i>quadrangularis</i> (Cissuslean<b>?</b>) on adipogenesis and high-fat diet (HFD)-induced obesity. The inhibitory effects of Cissuslean<b>?</b> on adipocyte differentiation were evaluated <i>in</i><i> </i><i>vitro</i> using 3T3-L1 preadipocyte cells, focusing on AMPK signaling and lipid metabolism. Subsequently, an <i>in</i><i> </i><i>vivo</i> trial with male C57BL/6J mice fed HFD was conducted to examine the effects of Cissuslean<b>?</b> at 25, 50, and 100 mg/kg on adipose tissue characteristics, body weight, fat mass, and obesity-related gene expression. Cissuslean<b>?</b> significantly inhibited preadipocyte differentiation by reducing intracellular lipid accumulation and suppressing the expression of key adipogenic regulators. It also enhanced AMPK phosphorylation during early adipocyte differentiation. In HFD-induced obese mice, Cissuslean<b>?</b> administration resulted in marked reductions in body weight gain, adipose tissue mass, and hepatic lipid accumulation. Furthermore, decreased serum ALT and AST levels indicated attenuation of HFD-induced hepatic injury. According to these results, Cissuslean<b>?</b> reduces body fat mass by inhibiting lipase activity and regulating genes and proteins involved in adipogenesis and lipogenesis in epididymal adipose tissue.  Our results suggest that Cissuslean<b>?</b> may be used as an anti-obesity agent.},
doi={10.12691/jfnr-13-1-2}
publisher={Science and Education Publishing}
}