@article{jfnr20241243,
author={{Li, Jiujiu and Wang, Ting and Zhou, Fuding and Xiao, Changchun and Liu, Zhengxiang and Yu, Jinchuan and Liang, Di and Wang, Guangjun and Shao, Changsheng and Wang, Peng and Chen, Wenjun},
title={Polygonatum Sibiricum Polysaccharides Alleviate CCl<SUB>4</SUB>-Induced Acute Liver Injury in Mice Via Reducing Inflammation and Oxidative Stress},
journal={Journal of Food and Nutrition Research},
volume={12},
number={4},
pages={182--195},
year={2024},
url={https://pubs.sciepub.com/jfnr/12/4/3},
issn={2333-1240},
abstract={From liver injury to hepatocirrhosis and hepatocarcinoma, irreversible progression correlates closely with inflammation. <i>Polygonatum</i> <i>sibiricum</i> has been reported to be beneficial to the liver, but its regulation of inflammation in liver injury has not been determined. Thus, we hypothesize that <i>Polygonatum </i><i>sibiricum</i> polysaccharides (PSP) play a protective role against acute liver injury by inhibiting inflammation and explore the underlying mechanism. The concentration and constituents of polysaccharides in PSP were identified first. We found that, like bifendate, PSP pretreatment significantly ameliorated acute CCl<SUB>4</SUB> exposure-induced liver injury and associated biomarkers. Meanwhile, PSP markedly attenuated inflammation and macrophage proinflammatory polarization both in the livers of CCl<SUB>4</SUB>-treated mice and LPS-treated Raw264.7 cells. Mechanistic investigation showed that PSP pretreatment markedly attenuated the activation of JAK<SUB>2</SUB>/STAT<SUB>3</SUB>/NF-¦ĘB signaling pathway in liver injury. Our findings demonstrated a novel understanding of PSP-mediated macrophage proinflammatory polarization in acute injury, which provides new knowledge regarding its application in acute liver injury treatment.},
doi={10.12691/jfnr-12-4-3}
publisher={Science and Education Publishing}
}