eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2024-03-29 12 3 160 167 10.12691/jfnr-12-3-8 JFNR20241238 article Raquel da Silva Vieira raquelvieira.biologia@hotmail.com 1 Eduardo Jos¨¦ de Arruda 2 Ant?nio Pancr¨¢cio de Souza 3 Danilo T¨®foli 4 Rosangela Assis Jacques 5 Patrick da Silva Mirowski 5 Ana Cristina Jacobowski 5 Maria L¨ªgia Rodrigues Macedo 5 Valter Arag?o do Nascimento 5 Rita de C¨¢ssia Avellaneda Guimar?es 5 Paulo Roberto Haidamus de Oliveira Bastos 5 Danielle Bogo 5 Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS, 79079-900, Brazil Faculty of Exact Sciences and Technology (FACET), Federal University of Grande Dourados, UFGD, Dourados, MS, Brazil Federal University of Mato Grosso do Sul, UFMS, 79079-900, Campo Grande, MS, Brazil Federal Institute of Education, Science and Technology of Mato Grosso do Sul, IFMS, Coxim/MS, Brazil Federal University of Rio Grande do Sul, UFRS, 91501 ¨C 970, Porto Alegre, RS, Brazil There is a need to find sustainable alternatives to control this arbovirus vector due the increasing resistance of Aedes aegypti to conventional chemical insecticides especially in tropical and subtropical countries. This study aims to evaluate the larvicidal potential of the Caryocar brasiliense fruit pulp as an eco-friendly alternative to the control of Aedes aegypti. Using mosquito third instar larvae, in vitro and in vivo toxicity tests were performed with the fruit pulp of Caryocar brasiliense. Larvicidal activity was observed at all concentrations tested, with no evidence of toxicity in vitro and in vivo, indicating safety for non-target organisms. The results suggest that the fatty esters present in the pulp of Caryocar brasiliense may be a promising alternative for the control of Aedes aegypti. These findings pave the way for further studies on the structure-activity relationship of natural molecules in combating mosquito-borne diseases. https://pubs.sciepub.com/jfnr/12/3/8/jfnr-12-3-8.pdf Caryocar brasiliense fatty acids larvicidal activity bioactive molecules eco-friendly