eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2024-03-10 12 3 115 124 10.12691/jfnr-12-3-2 JFNR20241232 article Ying Song 1 Haiming Yu 3399679593@qq.com 1 Department of Pharmacy, Shengli Oilfield Central Hospital, Dongying, Shandong, 257034, China Clear cell renal cell carcinoma (ccRCC) is one of the pathological types of renal cell carcinoma with poor prognosis, which poses a serious threat to human life. Therefore, there is a need to develop appropriate tumor markers to predict the development, treatment, and prognosis of ccRCC. As a member of a new protein family involved in ammonia transport in the mammalian kidney, RHBG plays an important role in the kidney. Therefore, the relationship between RHBG and clinical characteristics, prognostic risk, overall survival and immune infiltration in patients with clear cell renal cell carcinoma was explored by bioinformatics. The Cancer Genome Atlas (TCGA) database was used to evaluate the correlation between RHBG and ccRCC. The results showed that the expression of RHBG in renal cancer tissues was lower than that in normal tissues (P<0.001); ROC curve showed that RHBG had a high diagnostic value (AUC=0.957). The low expression of RHBG is associated with the immune status of renal clear cell carcinoma. These data suggest that RHBG is a viable potential biomarker for ccRCC with great potential for future clinical application and translation. https://pubs.sciepub.com/jfnr/12/3/2/jfnr-12-3-2.pdf TCGA ccRCC RHBG