eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2024-02-04 12 2 68 74 10.12691/jfnr-12-2-1 JFNR20241221 article Xinchao Yang 1 Xu Li 2 Yuanxiu Wang chm_wangyx@ujn.edu.cn 2 Chunjiang Ye 2 Yuehui Liu 2 Fang Wang 2 Naxin Sun 2 Bin Wang 3 School of Biological Science and Technology, University of Jinan, Jinan 250022, China China Resources Shenghai Healthy Technology Co., ltd., Zibo, China Shandong Huamei Biotechnology Co. Ltd., Jinan, China This study used mice as experimental materials to study the effects of ¦Ã-aminobutyric acid (GABA), rose and tryptophan on epilepsy. In addition, the combination of GABA, rose and tryptophan was studied to alleviate epilepsy. The optimal dosage of GABA, tryptophan and rose were determined to be 100 mg/kg, 160 mg/kg and 1.6 g/kg, respectively, according to the behavior of mice and oxidative stress indexes in serum. Screening the combination of GABA-compatible functional substances that can improve epilepsy, the optimal concentrations of GABA+ rose, GABA+ tryptophan, GABA+ rose + tryptophan were determined to be 10 mg/kg+1.4 g/kg, 10 mg/kg+170 mg/kg, 10 mg/kg+1.4 g/kg+170 mg/kg. Three kinds of whole nutrition food with the ability to relieve epilepsy in mice were obtained: GABA+ tryptophan (formula food 1), GABA+ rose (formula food 2), and tryptophan (formula food 3). Results showed that the three products had no significant effect on the body weight of mice, and the incubation period of epileptic seizure of mice was prolonged by 1 min. Meanwhile, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in serum increased, while the content of malondialdehyde (MDA) decreased. Combined with the new nutrition knowledge and advanced food processing technology, three kinds of whole nutrition medical food were prepared. This food has a good effect of relieving epilepsy, but also can meet the normal nutrient needs. https://pubs.sciepub.com/jfnr/12/2/1/jfnr-12-2-1.pdf GABA epilepsy medical food