eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2023-12-13 11 12 737 741 10.12691/jfnr-11-12-5 JFNR202311125 article Leilei Yu 1 2 Peifeng Li zhqd1963@126.com 2 2 Institute of Translational Medicine, Qingdao University, Qingdao 266021, China Bacterial infections caused by the misuse of antibiotics have gradually become a growing global problem. Highly toxic reactive oxygen species (ROS) are an ideal means of efficient and rapid sterilization, resulting in the leakage of bacterial contents by destroying bacterial membranes. In this study, we are to develop highly efficient Au@Pd nanospheres with peroxidase activity as antibacterial nanomaterials. The classical TMB chromogenic experiment showed that Au@Pd nanospheres had good peroxidase activity to produce ROS and achieve the antibacterial effect. Bacterial experiments have shown that Au@Pd nanospheres with peroxidase activity have great potential in inhibiting Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). https://pubs.sciepub.com/jfnr/11/12/5/jfnr-11-12-5.pdf bacterial infections peroxidase