eng Science and Education Publishing Journal of Cancer Research and Treatment 2374-2003 2024-03-01 12 1 1 7 10.12691/jcrt-12-1-1 JCRT20241211 article Ahmed M. Kabel ahmed.kabal@med.tanta.edu.eg 1 Shaimaa M. Kabel 2 Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt Colorectal carcinoma (CRC) represents one of the most commonly diagnosed malignant tumors worldwide. In spite of the continuous progress in diagnostic and therapeutic tools, CRC significantly contributes to cancer-related deaths all over the world. Early detection and treatment of patients with CRC may have a positive impact on prognosis, as the delay of diagnosis carries the risk of poor prognosis. Recently, new tumor biomarkers were discovered which can alone or together with the existing tests recognize either the predisposing factors or the early stages of CRC. Also, these biomarkers have the potential to determine the appropriate treatment algorithms by selecting the proper chemotherapeutic agents that can induce remission in a broad spectrum of patients. This review throws light on the tumor markers of CRC and their role in early diagnosis and determination of prognosis and the suitable lines of management of patients with CRC. https://pubs.sciepub.com/jcrt/12/1/1/jcrt-12-1-1.pdf colorectal cancer tumor markers diagnosis management