Science and Education Publishing International Journal of Dental Sciences and Research 2 4 2014 08 21 Primary Malignant Melanoma of the Oral Mucosa: Report of an Unusual Case 103 105 EN Btissaam. Belhoucha Department of ENT, CHU Med VI, Marrakech 2360, Morocco Zahra Essaadi Othmane Benhommad Youssef. Rochdi Hassan. Nouri lahcen. Aderdour M Khouchani Abdelaziz. Raji IJDSR2014248 10.12691/ijdsr-2-4-8 2014 08 11 2014 08 18 2014 08 21 Primary oral malignant melanoma is an extremely rare tumor, representing 0.2% to 8% of all melanomas; accounting for 0.5% of all oral malignancies The prognosis for a patient with oral melanoma is dismal, with a 5-year survival rate of 5% to 20%. A case is reported of a malignant melanoma in the mouth of a 81 year old male. The patient had a history of a continuously growing exophytic hyperplastic mass of a dark color. Histological examination revealed a melanin-producing tumour. Surgery was not offered to our elderly and medically compromised patient. Instead he received radiation therapy as the primary treatment and immunotherapy as the adjuvant treatment.