eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2024-12-24 12 4 56 61 10.12691/ajps-12-4-3 AJPS20241243 article Ackah Jacques Auguste Alfred Bognan 1 Yay¨¦ Yapi Guillaume yayeyapi@gmail.com, yaye_guillaume@ujlg.edu.ci 1 Obouayeba Abba Pac?me 1 Yobou¨¦ Yah Kan Monique 1 Djaman Allico Joseph 2 3 Heath Biology, Biochemistry-Microbiology Department, University Jean Lorougnon Gu¨¦d¨¦, BP 150 Daloa, C?te d¡¯Ivoire Biology and Health Laboratory, University F¨¦lix Houphouet-Boigny, 22 BP 582 Abidjan 22, C?te d¡¯Ivoire According to the WHO infertility an inability for a heterosexual couple to conceive after of regular unprotected sex, would affect about 17,5 % of the population. This highlights the extent of the problem of infertility on a global. Moreover, the female infertility rate is becoming increasingly worrying. Furthermore, limits to several was signaled medical treatments. The use of medicinal plants appears as an appropriate alternative. This study is to verify the therapeutic virtues of a decoction of Adenia lobata, Costus afer and Baphia nitida leaves traditionally used for female infertility by traditional practitioners (Côte d¡¯Ivoire). The mixture of the aqueous decoction from these 3 plant species were tested by gavage on female rats for 30 days at different doses of 400 mg/mL and 200 mg/mL. A phytochemical containing mancozeb was used as a competitive product to prevent fertility at concentrations of 500 and 250 mg/mL. Then a combination of this decoction and the chemical was also tested in the respective order of combination of 250-200 mg/mL and 250-400 mg/mL. The results revealed that this decoction showed a very interesting hormonal activity in the rabbits. It stimulates the production of hormones in the female (Estradiol and FSH) at a concentration of 200 mg/mL. This extract would be non-toxic on the vital organs at these doses. This decoction presents a better hormonal activity at the dose of 200 mg/mL and is not toxic to vital organs. https://pubs.sciepub.com/ajps/12/4/3/ajps-12-4-3.pdf Female infertility plant extract stimulation female hormon