eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2023-12-27 11 2 49 56 10.12691/ajps-11-2-4 AJPS20231124 article N¡¯Dri K. Eric D nericdonald@gmail.com 1 Assamoi A. Antoine 1 Ouattara H. Djeneba 1 Yao K. Jean-Noel 1 Universit¨¦ F¨¦lix Houphouet-Boigny, UFR Biosciences, Laboratory of Biotechnology, Agriculture and Valorization of Biological Resources of the University F¨¦lix Houphouet Boigny of Cocody, Educational and Research Unit in Biotechnologies, 22 BP 582, Abidjan 22, C?te d'Ivoire Garcinia kola seeds, an edible neglected wild fruit found in Asia and in tropical African countries, are characterized by interesting pharmacological properties which serve both for functional food and in the traditional treatment of cancer, diabetes, malaria, analgesics, hypertension and many other diseases. In the present study, we evaluated for 28 days the effect of oven dried powder of G. cola seeds in a fructose-salt induced hypertension model by analyzing biochemical and serum markers and organs. Biochemical assays revealed that G. cola seeds powder are rich in bioactive compounds with antioxidant activities higher than 80% and anti-inflammatory up to 60%, respectively. This powder has an antihypertensive strong effect observed by a decrease of systolic blood pressure (SBP) of 19 mmHg. Consumption of aqueous solution of G. kola seeds powder strengthens the immune system of the rats by balancing the components of the blood including HGB, LYM, PLT, WBC, HDL etc.. and protects their heart, liver, kidney. Thus, oven-dried powder of G. Kola has pronounced antihypertensive action with no adverse effects and, could be a sustainable alternative to conventional medical treatments of arterial hypertension. https://pubs.sciepub.com/ajps/11/2/4/ajps-11-2-4.pdf hypertension Garcinia Kola antioxidant anti-inflammatory