@article{ajmsm20251332,
author={{S¨¦v¨¦rin, Iri¨¦ Bi Jean and Parfait, Kahou Bi Gohi and Franceline, Goli Adjo Naomie and Anthelme, N¨¦n¨¦ Bi S¨¦mi and Jean-Claude, Abo Kouakou},
title={Hypotentive and Antihypertentive Effect of Leaves Aqueous Extract of <i>Saccharum officinarum</i>(Poaceae) on Rabbits},
journal={American Journal of Medical Sciences and Medicine},
volume={13},
number={3},
pages={34--39},
year={2025},
url={https://pubs.sciepub.com/ajmsm/13/3/2},
issn={2327-6657},
abstract={<b>  </b><i>Saccharum officinarum</i> L. (Poaceae) is a plant used in traditional medicine to treat high blood pressure. In order to provide a scientific basis, this study was undertaken. Thus, we carried out a study of the antioxidant activity and pharmacological tests on the leaves aqueous extract of <i>Saccharum officinarum</i> L. (Poaceae). The DPPH test showed that Esol contains antioxidants with an IC<SUB>50</SUB> of 0.5211 mg/mL. Pharmacological effects showed that Esol induced dose-dependent hypotension at doses ranging from 1 mg/kg B.W. to 20 mg/kg B.W., with a 50% Effective Dose of 5.17 mg/kg B.W. Interactions between the extract and pharmacological substances revealed that atropine had no significant effect (p > 0.05) on Esol-induced hypotension. The extract significantly reduced and cancelled (p &lt; 0.01; p &lt; 0.001) adrenaline and Isoprenalin-induced hypertension by 88.7 ¡À 6% and 81.88 ¡À 4.5% respectively, followed by hypotension of 46.9 ¡À 3.1% and 43.3¡À2.6%. These results justify the use of <i>Saccharum officinarum</i> in the treatment in cardiovascular disorders.},
doi={10.12691/ajmsm-13-3-2}
publisher={Science and Education Publishing}
}