eng Science and Education Publishing American Journal of Medical Sciences and Medicine 2327-6657 2025-08-17 13 3 34 39 10.12691/ajmsm-13-3-2 AJMSM20251332 article Iri¨¦ Bi Jean S¨¦v¨¦rin ijeanseverin@yahoo.fr 1 Kahou Bi Gohi Parfait 2 Goli Adjo Naomie Franceline 2 N¨¦n¨¦ Bi S¨¦mi Anthelme 2 Abo Kouakou Jean-Claude 2 Biology and Health Laboratory, Physiology and Pharmacology specialist, Felix HOUPHOUET-BOIGNY University, 22 BP 582 Abidjan 22, Ivory Coast Agrovalorization Laboratory, Physiology and Pharmacology specialist, Jean LOROUGNON GUEDE University, BP 150 Daloa, Ivory Coast Saccharum officinarum L. (Poaceae) is a plant used in traditional medicine to treat high blood pressure. In order to provide a scientific basis, this study was undertaken. Thus, we carried out a study of the antioxidant activity and pharmacological tests on the leaves aqueous extract of Saccharum officinarum L. (Poaceae). The DPPH test showed that Esol contains antioxidants with an IC50 of 0.5211 mg/mL. Pharmacological effects showed that Esol induced dose-dependent hypotension at doses ranging from 1 mg/kg B.W. to 20 mg/kg B.W., with a 50% Effective Dose of 5.17 mg/kg B.W. Interactions between the extract and pharmacological substances revealed that atropine had no significant effect (p > 0.05) on Esol-induced hypotension. The extract significantly reduced and cancelled (p < 0.01; p < 0.001) adrenaline and Isoprenalin-induced hypertension by 88.7 ± 6% and 81.88 ± 4.5% respectively, followed by hypotension of 46.9 ± 3.1% and 43.3±2.6%. These results justify the use of Saccharum officinarum in the treatment in cardiovascular disorders. https://pubs.sciepub.com/ajmsm/13/3/2/ajmsm-13-3-2.pdf Saccharum officinarum antioxidant hypotensive antihypertensive