@article{ajmsm20251312,
author={{Derosa, Giuseppe and DĄŻAngelo, Angela and Gaudio, Giovanni V. and Guasti, Luigina},
title={Effects of A Food Supplement Containing Oleuropein, Elenolic Acid, Rutin, Hydroxytyrosol and Tyrosol in Patients with Hepatic Steatosis},
journal={American Journal of Medical Sciences and Medicine},
volume={13},
number={1},
pages={8--14},
year={2025},
url={https://pubs.sciepub.com/ajmsm/13/1/2},
issn={2327-6657},
abstract={Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of liver disease and is characterized by obesity, hyperglycemia, insulin-resistance, dyslipidemia and hypertension. The aim of this study was to evaluate if Olife? consumption in patients with NAFLD could improve fatty liver grade and related metabolic and inflammatory parameters. Eighty-two Caucasian patients aged ≥ 18 of both sexes diagnosed with NAFLD, according to practice guidelines, were enrolled in a single-center, double-blind, open label, randomized, controlled study. Patients were randomized to follow a standardized Diet or a standardized Diet + Olife? for 3 months. No changes in BMI, circumference, FPG, TC, LDL-C, HDL-C and Tg were observed with either treatment. In the group of patients receiving Diet + Olife?, a significant decrease in hs-CRP and TNF-α as well as an increase in ADN (p < 0.05 compared to Baseline and Diet) was observed, respectively. Transaminases and γ-GT were significantly reduced (p < 0.05 vs Baseline and Diet) in Diet + Olife? group compared to Diet group, respectively. In addition, AST/ALT ratio and HIS were significantly lower (p < 0.05 vs Baseline and Diet) in the Diet + Olife? group compared to Diet group, respectively. All patients showed signs of hepatic steatosis improvement or disappearance. In conclusion Olife? added to Diet ameliorates hepatic parameters and echography grading, and manages to reduce inflammatory parameters during the 3 months of study.},
doi={10.12691/ajmsm-13-1-2}
publisher={Science and Education Publishing}
}