eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2024-09-25 12 9 138 140 10.12691/ajmcr-12-9-2 AJMCR20241292 article Singh Ria BS ria.singh@kansascity.edu 1 Cotant Matthew B MD 2 Krishnan Anant MD 3 Kansas City University College of Osteopathic Medicine 1750 Independence Avenue, Kansas City, Missouri, 64106 Corewell Health William Beaumont University Hospital 3577 West 13 Mile Road, Royal Oak, Michigan, 48073 Corewell Health William Beaumont University Hospital3601 W 13 Mile Rd, Royal Oak, Michigan, 48073 Leukostasis, which refers to increased blood viscosity due to the increased white blood cell count, is a critical condition observed in acute myeloid leukemia and is associated with significant morbidity and mortality. The excessive accumulation of white blood cells can lead to the occlusion of small vessels in various body parts such as brain and lungs, resulting in corresponding clinical symptoms. We discuss a patient with history of breast cancer and newly diagnosed leukemia whose head CT revealed multiple defined hemorrhages that were suspected to represent hemorrhagic metastasis. Findings on serial imaging and correlation with patient¡¯s blood work, led to an alternate diagnosis of leukostasis with intracranial manifestations. This was also confirmed on the subsequent MRI. The intracranial involvement of leukostasis is rarely discussed in practice or literature such that we hope our case report will facilitate increased awareness of the condition. https://pubs.sciepub.com/ajmcr/12/9/2/ajmcr-12-9-2.pdf Acute myeloid leukemia leukostasis hemorrhages white blood cells blood viscosity