eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2024-03-02 12 2 24 28 10.12691/ajmcr-12-2-4 AJMCR20241224 article Abdulhameed Alsarraf Abdulhameed.alsarraf@hotmail.com 1 2 Shaima Aldhafeeri 2 Woroud N. AL-Sulimmani 3 Oral Medicine Clinic, Ministry of Health, Jahra Medical City, Kuwait Oral & Maxillofacial Surgery Department, Ministry of Health, Kuwait Pemphigus vulgaris (PV) is a rare chronic autoimmune mucocutaneous blistering disease characterized by the production of autoantibodies targeting desmogleins, key components of intercellular adhesion of keratinocytes. This process leads to the loss of intercellular adhesion, culminating in the development of intraepithelial bullae and erosions. PV manifest as intraoral lesions that subsequently spread to other mucous membranes and the skin. While the exact etiology remains elusive, several triggering factors have been identified. Oral lesions of PV are often misdiagnosed and mistreated, emphasizing the need for early recognition by dental professionals. This case report aims to contribute to the existing literature by illustrating representative clinical features of PV, diagnostic approach, and therapeutic challenges associated with our case. https://pubs.sciepub.com/ajmcr/12/2/4/ajmcr-12-2-4.pdf pemphigus vulgaris oral ulceration autoantibodies autoimmune