Science and Education Publishing American Journal of Medical and Biological Research 2328-4099 3 4 2015 06 03 Integrated Planetary Outpost Simulation to Assess Crew Psychophysiological Response as a First Approach to a Lunar/Mars Manned Base Settlement 107 112 EN Lynn Van Broock Pablo de León Daniel E. Vigo Laboratorio de Neurociencia Aplicada y Espacial – Instituto de Investigaciones Biomédicas Facultad de Ciencias Médicas Universidad Católica Argentina / CONICET. Alicia Moreau de Justo 1500. C1107AAZ – Ciudad Autónoma de Buenos Aires, Argentina AJMBR2015345 10.12691/ajmbr-3-4-5 2015 05 02 2015 05 12 2015 06 03 One of the most effective and complex concepts in planetary settlement is the integration of interfaces such as habitat modules, rover vehicles and space suits that can connect via airlocks, suitports and tunnels, and can disconnect to operate independently. This scenario is ideal to assess common symptoms during spaceflight missions such as fatigue, sleep loss, circadian desynchronization and work overload, This paper describes the main features of an integrated system built at the Human Spaceflight Laboratory from the Department of Space Studies at the University of North Dakota and a series of feasible measurements that can be conducted there to assess psychophysiological responses of a crew during confinement. This approach may contribute in the analysis of environmental mission conditions that interfere with sleep quality and individual vulnerabilities associated to sleep loss and circadian desynchronization.