eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2016-10-27 4 3 43 46 10.12691/ajcmr-4-3-2 AJCMR2016432 article Rizki Handayani rizkihr@gmail.com 1 Meita Dhamayanti 1 Nanan Sekarwana 1 Department of Child Health, Dr. Hasan Sadikin General Hospital-Universitas Padjadjaran, Bandung, Indonesia Objective Analyze the differences in TC, LDL, and HDL levels between smokers and non-smokers adolescent. Study Design This analytical cross-sectional study was performed during February to April 2016 in several senior high schools in Bandung. Subjects were adolescent, aged 15?18 years, who were divided into two groups: smokers and non-smokers using questionnaire. There were 206 boys included in this study, 162 met the inclusion criteria and 44 were excluded. Simple random sampling was performed to obtain 50 smokers and 50 non-smokers for our study. All data were analyzed for mean serum lipid profiles using chi square (x2) and MANOVA test with a p value <0.05 considered significant. Results The x2 analysis showed association between abnormal serum TC, LDL, and HDL levels with smoking status respectively (p=0.006, p=0.025, and p=0.006). MANOVA test results showed significant differences between smokers and non-smokers group in terms of mean±SD TC level (161.7±32.2 and 150.6±19.5), LDL (107.6±29.2 and 92.6±92.6), HDL (38,76±6.39 and 42.8±7.08)) with p value <0,05.Conclusion This study shows that serum TC, LDL, and HDL levels in smokers are statistically different compared to those in non- smokers adolescent. http://pubs.sciepub.com/ajcmr/4/3/2/ajcmr-4-3-2.pdf smoking adolescent lipid profile